Dementia Predictors in Parkinson Disease: A Validation Study.
Identifieur interne : 000099 ( Main/Exploration ); précédent : 000098; suivant : 000100Dementia Predictors in Parkinson Disease: A Validation Study.
Auteurs : Julius B M. Anang [Canada] ; Takashi Nomura [Japon] ; Silvia Rios Romenets [Canada] ; Kenji Nakashima [Japon] ; Jean-Francois Gagnon [Canada] ; Ronald B. Postuma [Canada]Source :
- Journal of Parkinson's disease [ 1877-718X ] ; 2017.
Abstract
In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson's disease. Here, we validate these dementia predictors using two additional prospective cohorts (n = 134). After a 3.6-year follow-up, 35/134 developed dementia (7.2% per year). When confirming individual variables, 5/8 were significantly associated with dementia in the validation cohort. These included age, male sex, baseline RBD, orthostatic hypotension, and MCI. Bilateral onset, hallucinations and falls/freezing did not significantly predict dementia; however, point estimates of OR were all >1. In all cohorts, the strongest determinant for dementia development was the co-existence of RBD, MCI and orthostatic hypotension at baseline.
DOI: 10.3233/JPD-160925
PubMed: 27911340
Affiliations:
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Postuma</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, McGill University, Montreal, QC</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Parkinson's disease</title><idno type="eISSN">1877-718X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson's disease. 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